A computer-implemented method of indexing an electronic database record to facilitate searching is provided, as well as a method of performing a search using the index. Also disclosed are methods for the screening of substances and genetic constructs that inhibit SHIP function in mammalian cells, and cell lines and transgenic animals that have the SHIP phenotype. A solid lubricious material is applied between the threading and the threaded fastener to facilitate easier installation, increased locking forces, and decreased distortion of system components.