A fastener system includes a screw or bolt having two interleaved helical threads which bracket a helicoil. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. The cassette or an endcap enclosing the cassette is marked with a fiducial indicating and corresponding to the location of the excision on the patient’s body. A bottom-up schematic algorithm includes a linear parameterization of a ratio of an order from a plurality of source topics to a plurality of sink topics of an article, and a horizontal schematic algorithm includes an order parameterization by absolute differences of a log of a plurality of ranks and an absolute difference of a plurality of distances with analogous cutoff methods. Based on whether the composition is appropriate, timing to record the image data is determined.