Two novel sphingomyelinases are provided, having optimum activities at pH7 and pH8, respectively. The multiple VMs have their own layer 2 and layer 3 addresses, but they share a common network connection for which only a single layer 2 address may be used, such as in the case of a standard wireless network interface card or in the case of multiple NICs and a standard NIC teaming solution. The substrate includes a first major surface with a first longitudinal edge and a second longitudinal edge. The substrate is etched using the patterned masking layer to produce a template.