The invention relates to a counterfeit-proof marking having a carrier layer having a communicating pore space and a probe formed from a first biomolecule contained therein. The anti-fraud bottle cap of the present invention includes a valve seat, a lower end of which is fitted in an opening of the bottle to guide outflow of fluid contained in the bottle, and a valve unit which is seated in the valve seat and opens and closes a fluid flow passage of the valve seat. The hybrid protein also contains a protease cleaving proteins of the secretion process of the mastocytes and basophils so as to inhibit the secretion process without killing the mastocytes and basophils.