The present invention relates to compounds of formula for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. The invention also provides a driver and methods for advancing needles, cannulas, and other medical devices through the pubic bone. The signal paths of the board is not exposed at the edge of the circuit board. The driving assembly includes a cam indexer engaging with the cutter storing frame for rotating the cutter storing frame.