A methodapparatussystem for educational intervention based on a response metric is disclosed. Anonymous access is unlinkable to any previous or future accesses of the user at the RP. The methods involve the administration of the tablets of the invention to individuals in need of administration of such tablets. A CBM normalization matrix is calculated. The sense amplifier further includes a cross-connected feedback inversion circuit which inverts a sense amplifier output signal from a first latch inverter for application to a conducting line of a second latch inverter.