An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. The invention is characterized in that it comprises means for analyzing the loading state of the pollution management means and means for comparing same to threshold values, to implement the first regeneration strategy for states with load lower than the threshold values or the second regeneration strategy for states with load higher than the threshold values. The method for aligning semiconducting nanowires on a metal electrode in accordance with the present invention makes it possible to manufacture multiple nanowire devices at low cost. The barrel axis intersects the cutting end axis at an obtuse angle. The interposer may be configured to attach the ball grid array package to the circuit board such that each of the solder balls on the ball grid array package contacts at least a portion the plurality of pins and at least a portion of the plurality of pads and such that the each of the plurality of pins also connects to a contact on the circuit board. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.