Methods of treating or preventing cardiovascular disease andor inflammatory disease in mammalian subjects comprising the administration of the novel formulations disclosed herein are provided. , at a pressure in the range of ambient to 150 psi and collecting the products at a temperature ranging between 5 to 5 C. The antibody, when penetrating into cells by itself or ectopically expressed within cells, binds specifically to single- or double-stranded nucleic acid targets and hydrolyzes them, thus downregulating the expression of the targeted genes.