Connection electrodes are formed to be located on the same plane as discrete internal electrodes, and to be exposed to the rear face while being insulated from the discrete internal electrodes. The fiber optic line has a breakaway connection that severs when the completion inner string is removed. for 1 to 60 minutes, the number of twist in the untwisting step is 1. In addition, the measure of the severity of the inattentiveness of the driver depends on at least one driver-specific parameter which is determined during the execution of the method. The invention also provides methods of using the combinations for the treatment of diseases associated with cell proliferation, such as tumors.