This invention relates to methods for altering the splicing of mRNA in cells. The image sensor chip has an active surface, a back surface and a plurality of side surfaces, wherein a sensor region is formed in the active surface. , to a method and application for the treatment andor prophylaxis of tumors andor infections in the central nervous system andor other parenchymal organs in mammalian subjects. Alternatively, 3,3-dimethylbutanal is prepared from 3,3-dimethylbutanol obtained by reduction of the corresponding carboxylic acid or 1,2-epoxy-3,3-dimethylbutane, or by hydrolysis of 1-halo-3,3-dimethylbutane. Additionally, an annular space is formed around the baffle plate so that atmospheric air from the baffle plate flows through the annular space to the filter. The modular brush head and modular handle allows handles with different designs to be fitted with brush head that has different bristle arrays to fit individual brushing needs.