Some aspects provide determination of a function to rectify functional differences between netlist G1 and netlist G2 having inputs V. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of receptors and enzymes related to the generation and activity of such nucleotides. The method also includes determining a number of control vector symbols onto which to map each of the M control signals based on a respective value Q\u2032 calculated for that control signal, mapping the control signals for that control signal, and transmitting the control vector symbols.