Cyclooxygenase-2 enzyme inhibiting withanolides are described. The lace locker fixedly attached near the top of the upper, preferably to an upper portion of the tongue. The queues are weighted such that the weight of a queue defines the relative share of resources allocated to said queue in relation to the resources that are to be allocated to the other queues. Finished product applications and unitized composite webs suitable for finished products employing the inventions are provided.