The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators. The sample microarray of this invention is formed by distributing equivalent amounts of a single sample at discrete, spatially defined locations on a substrate. This system configuration results in improved NOx conversion due to faster SCR catalyst warm-up and higher operating temperatures. The border area may be laser shock peened with progressively lower fluence oblique laser beams starting with the one first fluence oblique laser beam wherein the progressively lower fluence oblique laser beams are in order of greatest fluence to least fluence in a direction outwardly from the first area through the border area to the non-laser shock peened area. The tiered security software protocol is configured for large scale distribution of electronic Subscriber Identity Modules.