Optical systems of the present invention generally include at least one optical amplifier having a first pump source configured to supply power to said amplifier via a first pumping paths. According to the present disclosure, there is provided an automatic favorites registration method and system which can automatically register a website which a local computer accesses, and also can register only an additional website which is determined to be optimal for a user’s convenience, or maintain a favorites registration of the website according to the user’s recent search trend. The image merging unit is used for merging the 3D structure images into the 3D blood vessel photographic images, therefore choosing a blood vessel passage fully covering the target cells for transmitting the macromolecule substances. This system is known as an internalexternal melt system because the thermal energy, stored in the form of ice, is melted internally by a primary heat exchanger and externally by circulating cold water from the periphery of the block through a secondary heat exchanger.