An FPD has plural pixels arranged in two dimensions. The method includes providing a sirtuin substrate having the formula: providing NAD+ or an NAD+ analog having the formula:and providing a sirtuin, wherein R1-R4, A1, A2, and n are as defined herein. If the figure for search is equal to or smaller than the figure in the ten’s digit of the quantity number of titles, the figure inputted for search is registered as a figure in the ten’s digit. A bore extends through the head and shank from the proximal end to the distal end and the bore has a polygonal cross-section through the anchoring portion.