A method for treatment of benign prostate hyperplasia, prostate cancer, estrogen-dependent breast cancer, endometrial cancer, ovarian cancer, endometriosis and precocious puberty, or for use for contraceptive purposes or in an in vitro fertilization programme, or for treatment of sex offenders is provided. The modified develop finds other applications. The first zipper part passes through a first space between the first sidewall and the plow, while the second zipper part passes through a second space between the second sidewall and the plow.