A roller guiding method for delivery of magnetic tape media along a tape path between a tape drive employing a single reel and a tape cartridge employing a single reel. A plurality of gate lines, gate electrodes and gate extension lines are formed by depositing and patterning a first metallic material using a first mask. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. coli and anaerobic bacteria, which are harmful to the human body, in the natural product, and it also can prevent the generation of bed smells in the natural product. A heat conductive substrate is provided with an insulator body formed by heating and pressurizing said composition for substrate materials and a wiring pattern is provided in such a condition that it is exposed on the surface of the insulator body. The pistons with piston rings are inserted into cylinder bores through the bottom surface of the cylinder block and the assembly is completed.