Novel substituted 1,5,7-trisubstituted-1,8-napthyridin-2-one compounds; 1,5,7 trisubstituted-1,6-napthyridine-2–one compounds and 1,5,7-trisubstituted quinoline-2-one compounds, processes for the preparation thereof, the use thereof in treating CSBPp38 kinase mediated diseases and pharmaceutical compositions for use in such therapy. A database arrangement is linked to the nutrition dispenser, and further, the nutrition dispenser typically includes the user interface for feeding at least the information of the user, and rooms for storing different nutrients andor medical substances. Preferably, the simulation sites are selected by initial simulation within a region of influence of the vertices of mask shapes. This allows the protocol mapping to be updated to reflect any changes to communication protocols that may occur without having to update any compiled software. By use of this invention, the packet forwarding speeds in a conventional computer architecture may be increased.