Methods and compositions are provided for decreasing PGE2:PGF2\u03b1, regulating ratios of zinc:cadmium and regulating the concentration of zinc, calcium and zinc-containing and PGE2-dependent matrix metalloproteinases in body fluids and tissues of a human. A die or chip is mounted in a fixed relationship to the glass substrate, and is often mounted on the glass substrate. The hybrid memory may also include a hybrid memory buffer chip attached to the first side of the package substrate. The method includes permitting the user to select a link in an annotation.