The present invention provides methods and compositions for enhancing the activity of various therapeutic agents that induce apoptosis by modulating the apoptosis-inhibiting effects of the expression products of mutant epidermal growth factor receptor genes. More particularly, the present invention concerns methods and apparatuses for creating double-wall blow-molded components with one or more protuberances not abutting a parting line of a mold. A second opto-electric conversion unit converts a portion of output optical signals output from the optical fiber amplifier into electrical signals and then outputs the converted electrical signals. A first etching process is thereafter performed to remove a specific thickness of the second conductor followed by a first ion implantation process to dope the second conductor with the first type dopants. The aggregate of actual shares may be placed on a book and rounded down to the nearest round lot for displaying on the round-lot-based system. The conditioning system has fluid outlet passages to supply conditioning fluid to the area to be conditioned and is configured to adjust outflow of the conditioning fluid from the fluid outlet passages depending on a position of the object.