The present invention relates to a method and system for supporting in a router a plurality of data flows using a ternary content addressable memory in which the number of accesses to write to the TCAM is optimized to improve efficiency of updating and subsequent look up. The invention further related to the resulting N-terminal modified rhEndostatin protein, a pharmaceutical composition containing the same, and use of said modified rhEndostatin or its pharmaceutical composition in treating the angiogenesis-related diseases, especially angiogenesis-dependent tumors. The high temperature bond is preferably a mechanical bond, with the wafer and substrate having respective bonding pads which are aligned and mechanically connected to form a thermocompression bond to effect the bonding. The selection method is not affected by environmental or climatic conditions.