A controlled temperature therapy system has a pump, a reservoir, and a therapy component. The gaming machine includes a first wireless transceiver. Moreover, the invention provides a mobile node and a proxy acting on behalf of the mobile node. A method of responding to predetermined events comprises detecting a movement of a handheld electronic device away from a first configuration toward a second configuration without reaching the second configuration. The composition is useful for the treatment or prevention of a cancer, a tumor or an inflammatory disorder, particularly breast cancer. Pages of the photobook incorporate a plurality of images in the group.