The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The hexalobular drive hole can include points having an outermost portion, and the head can include an outer surface, where a thickness of about 0. A drug-impermeable backing overlies the first surface of the reservoir. Then, a voltage is applied between the first electrode and the second electrode with a state where a potential of the first electrode becomes higher than a potential of the second electrode to remove a carbon fiber through which the first electrode and the second electrode are short-circuited. After the ions are implanted in the substrate below the trenches, the remainder of the trench can be filled with the same or another dielectric material. In some cases, the user can input information about an acceptable penalty.