De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The material is a film containing titanium oxide onto polymer sheet. A first source region and a second source region are formed in the well, and the first source region and the second source region have a second type doping. The PTFE resin composition, which is prepared by blending a specific amount of curved carbon fibers with PTFE or modified PTFE, can be effectively used as a molding material that can provide a water pump lip seal material having excellent deformation resistance, abrasion resistance, and sealing properties against cooling water.