The present invention provides methods, a server and a system for adjusting the operation of an application of a server during operation of the server. Analysis cassettes, systems of analysis cassettes, supplemental modules, and methods for producing analysis cassettes are also described. The reaction force varying device also varies a reaction force increase rate at a first increase rate during a first reaction force increase period of the increase of the reaction force, and at a second increase rate during a second reaction force increase period of the increase of the reaction force. A conductive interconnect element extends from the fuel cell subassembly to make contact with the next cassette in a stack. In other embodiments, the support is made of composite construction materials, and having a self-drilling capability. For each communication item, the server also maintains an index explicitly identifying each item in its native system, so that access to disparate systems is enabled without replicating functionality or data.