A method is described for the detection of the degree of methylation of a specific cytosine in the sequence context 5-CpG-3 of a genomic DNA sample. With such methods, a cast body of a geometrically ordered multi-crystalline form of the one or more of a semiconductor, an oxide, and an intermetallic material may be formed that is free or substantially free of radially-distributed impurities and defects and having at least two dimensions that are each at least about 10 cm. For example, the host device andor application programs executing thereon can be configured to restrict a user’s ability to invoke program functionality that accesses sensitive information based on whether a verified session with a wearable device is currently in progress.