A transponder includes an antenna, a modulationdemodulation unit that modulates and demodulates signals received and transmitted from and to a controller, a pressure resonator including a first piezoelectric single-crystal resonating element and a pressure sensor. Compared to either approach used alone, this combined targeting approach resulted in a dramatic improvement in the target: non-target transgene expression ratio in vivo, thereby improving the prospects for pulmonary vascular gene therapy and establishing a fundamental principal for the use of targeting strategies generally. The programmed memory cells in the first memory array block may be programmed with predetermined data during a semiconductor manufacturing process, and may be mask read-only memory cells. Customer commitment to the second solution is obtained. Openings are formed in the perimeter in communication with the gate-receiving area.