A CMOS transistor is provided having a relatively high breakdown voltage. Two phosphorodiamidate morpholino oligomer probes that differ by at least one base are each covalently coupled to a nano article and hybridised to a target sequence. The loading plate may allow the height of the RF antenna structure above the ground plane to be relatively small. Advantageously, the systems and methods of the present invention generally preclude fluid communication between the annulus of the upper completion section and the flowbore of the lower completion section until the lower completion section is closed off to fluid flow. The preferred plasticizer is glycerol and the preferred vegetable oil derivative is the maleinized methyl ester of tung oil.