Locking device that is mounted on an endoscope or the like for selectively securing the position of a guide wire andor catheter relative to the endoscope or the like. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. As a result, a continuous curved surface can be achieved at the boundary between each tapered portion of each obtained glass part and the internal hole thereof, and the surface can be made smooth where the tapers are formed. The buffer circuits being configured so as to substantially equalize relative impedances seen towards said outputs. Additional embodiments are disclosed. A number of ESM units are connected to a control centre.