The present invention relates to Pyrimidine Ether Derivatives, compositions comprising a Pyrimidine Ether Derivative, and methods of using the Pyrimidine Ether Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor in a patient. An apparatus according to aspects of the present invention includes an absorption region including a first type of semiconductor region proximate to a second type of semiconductor region. The CPA 9 includes a first finger piece 92 having a first bent protrusion D1, second finger pieces 91, 93 each having a second bent protrusion D2, and a spring-force-accumulated part. The unique invention special dopant region is located under and around the NMOS drain which lowers the drain to substrate breakdown voltage enabling the ESD protection current discharge to start at a lower voltage than otherwise. The arch bridge has a lower surface that is at least in part visible from outside the shoe and has a portion that is approximately planar with the lower surface of the plate for at least a substantial portion of the full extension of the arch bridge as measured along an axis that is parallel with the major longitudinal axis of the shoe.