A cylinder of a printing press is provided with an axial bore in which a fluid supply line is supported by spacers forming a return duct having an annular cross section, so that the inlet and the outlet of the fluid are at the same end of the cylinder. RPM is determined based upon the input of a digitized time-based sample sequence of vibration data acquired directly from a vibration transducer for on-line real-time measurement of the machine RPM. This effect is obtained by combining 3TC, in usual doses, with a reduced dose of ddC, in the same pharmaceutical formulation. The image pickup system includes a calculating section which has an AF mode which generates a defocus signal by comparing mutually the signals for detecting the amount of defocus which have been output from the two photoelectric conversion cell groups, and a correction section which corrects the signal for detecting the amount of defocus, from information related to distortion of the taking lens. for 2-10 hours in an aprotic polar organic solvent which is strongly alkaline.