The present invention relates to \u03b17 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System such as cognitive deficits in schizophrenia, by administering to a mammal an \u03b17 nicotinic receptor agonist of formula I as shown herein. In a further embodiment of the foregoing embodiment, the fire shield includes a sheet metal alloy layer. Therefore, the body part can smoothly enter the cuff apparatus and the flow of blood can be sufficiently suppressed. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient.