An introducer sheathtemperature probe assembly that is insertable into a blood vessel of a human or veterinary patent to measure the temperature of blood flowing through that blood vessel. The device has a body with a rounded side for sanding concave recesses, sharp corner edges for use in sanding ninety-degree corners, and flat surfaces for sanding planar areas. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.