Systems and methods for dynamic development and deployment of computing applications including a development framework, a visual design subsystem, and a deployment subsystem, where at runtime the deployment subsystem is operable to dynamically deploy a computing application by sending a request at runtime for graphs and components identified in the computing application. Thermal isolation is further enhanced by making the planar electrodes from a metal with lower heat transfer than typical electrical metals. Specifically, subjects undergoing chemotherapy are first exposed to a pretreatment regimen.