The invention provides materials and methods capable of modulating the strong-self-association of chimeric transcription factors to form high molecular weight complexes. A preferred embodiment of the present invention comprises a cartridge including a microfabricated silicon chip on a printed circuit board and a flow cell mounted to the chip to form a flow chamber. A mask is disposed in a region opposite to a testing terminal, and ITO is sputtered, thus forming a common electrode. In the area, the large gear includes a first special tooth, a second special tooth, and a space between the first and second special teeth. The implement is used in applying a transdermal lotion to the axilla area of a user.