A Josephson junction device includes a buffered substrate comprising a first buffer layer formed on a substrate. Various additional embodiments provide methods of high throughput screening for gene amplification. The coupling device is formed in particular in such a way that electrical energy can be inductively picked up from the current conductors running in the floor covering. In preferred embodiments, the disclosed compositions will be used in conjunction with inhalation devices such as metered dose inhalers, dry powder inhalers, atomizers or nebulizers for targeted delivery of the agent to mucosal surfaces. The method includes equalizing received serial data in the equalizer, detecting an error in equalized serial data output by the equalizer, and determining reset of the equalizer in relation to an error detection.