The invention relates to a valve device comprising a valve body defining a fluid flow duct having a throttle element disposed therein and turned about its axis by actuator means via a drive shaft, the throttle element having an internal cavity defined by a circular wall that is open in its bottom portion. The method of manufacturing the electronic device requires a fewer number of processes and comprises a direct patterning of insulating layers, such as fluorinated organic polymer layers, is possible using cost-efficient techniques such as inkjet printing. cancer using intracellular and extracellular extracts.