The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. The change in air pressure or air flow, which is caused by the consumer forcing air through the air permeable cigarette, causes the switch to close thereby allowing the lighter’s direct current power supply to increase the temperature of the lighter’s heating element above the cigarette’s ignition point. Exemplary therapeutic electrical stimulation devices include a shoe connected mechanically and electrically to a conductor that provides signals for electrical stimulation.