Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. A bulk actuator at the other end for actuating the fluid for ejection through the aperture. The cancellation request is a request from a customer to modify an ordered quantity of the one or more items according to a cancelled quantity indicated in the cancellation request. Alignment of the pivot joint with the growth plate promotes asymmetric growth of the growth plate to thereby correct the angular deformation. The frequency coefficients from multiple data streams may be partitioned into tone groups, and all the frequency coefficients from a given tone group may be redistributed in accordance with a single matrix for that tone group.