The manufacturing yield of semiconductor devices is improved. The present invention provides a means for measuring environmental factors, such as osmotic pressure, simply and with high accuracy. A low-order floating-point filter and a first set of parameters associated with the low-order floating-point filter components are then selected. Methods of using this unique cell line for pharmacologic screening are disclosed. The guide channel has a cross-sectional profile that is designed to correspond to the cross-section of the plate shaped implant body.