Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin. In response to a wager from a player, the machine conducts a selection game including a plurality of selectable elements associated with respective outcomes. The computer personality includes customization choices, data files, electronic mail, system preferences, application customization choices, the network environment, browser information, etc. The current sensor generating an output signal in response to the detection of the electrical signal for controlling the signaling device for monitoring the status of the signaling device. Both the temporal and spectral responses are actively changed on each iteration of the energy recirculation. An index of evaluating a vehicle distance change is calculated based on a relative vehicle speed, wherein the index has a characteristic feature according to which the index value is increased as the relative vehicle speed becomes higher and a vehicle distance becomes shorter.