Collection, access and management of controlled-access digital image data across disparate image data protocols from different sources, for example, clinical-quality and communicative-quality images of all types used in the practice of medicine, is achieved using a digital image collection and library system over a wide area network. The peripheral sidewalls of the pleated filter are attached to the frame generally by an adhesive. The delivery port is in fluid communication between the interior chamber and the central open space. Particular embodiments include a dosage form that provides a controlled release of oxybutynin and the second drug to maintain therapeutically effective levels oxybutynin andor the second in a mammal for an extended period of time. Even when the channels are independent, skew is substantially eliminated by monitoring to determine when all channels have reached their active states, and only then allowing data to flow between the serial and parallel domains.