A probe having a conductive body and a contacting tip that is terminated by one or more blunt skates for engaging a conductive pad of a device under test for performing electrical testing. In one embodiment, the pyrimidine derivative is capecitabine and the camptothecin derivative is CPT-11. A hybrid circuit is assembled in the case. The method also includes generating the metrology sampling plan based on results of the identifying step such that one or more areas on the wafer in which the one or more identified individual defects are located are sampled during metrology. These compositions may be prepared, for example, by sonicating a mixture comprising the solid calcium salt of L-leucovorin and water. These compounds inhibit PDE10A and can be used as pharmaceuticals.