The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively ; has an agonist activity; and binds to human CD40. The desired received signal is spread using code division multiple access. For example, in a flatbed scanner a linear array of scanning devices is positioned across the document in a first or x direction and this array is moved across the document in a perpendicular or y direction.