The present invention pertains to a method for treating a pulmonary disease state in mammals by altering indigenous in vivo levels of nitric oxide in mammalian cells. A second PLL circuit receives a horizontal synchronizing signal and the flyback delay signal as a reference signal and a compared signal, respectively, and generates a horizontal drive pulse. A method for a performing an operative procedure on a target tissue in a subject using the endoscopic surgical device is also described. The method further includes generating a second event grouping including a second set of the events based on both the local times and the timezones of the events. In one configuration, the proximity searcher resides on a server coupled to a network and responds to user queries provided by, for example, client computers also coupled to the network.