Screening of a library of particles in vivo andor in vitro using Polyplex Iterative Combinatorial Optimization allows for the design of particles for targeting a specific organ, tissue, or cell. The sheath is made of a pair of confronting gelatin sheets as starting material. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer. To create the 45 degree angle beam shear waves for the circumferential scans, the ultrasonic sensor is offset from the centerline of the cylinder, creating the correct angle for excitation of the shear wave. The timing between pollings of the server is thus changed based on the amount of data downloaded from the server during the pollings of the server. The toner contains a colorant and a binder resin, and also contains a polyolefin resin containing a polar group and having a glass transition point of 20\xb0 C.