Automated systems and methods for adapting semiconductor fabrication tools to process wafers of different diameters are described. Optical axes of the plurality of laser beams constituting the beam bundle outputted from the output section intersect with each other at a single point without relying on the F-axis converging lens. The linear phase-error signal is injected using an ultra-low latency delay path. When either or both flags are on, the packet buffer changes focus to a second connection and begins buffering second packets on the second connection. In certain aspects, the compositions of the invention are capable of generating both a vascular targeting effect and tumor cell cytotoxicity in order to achieve an enhanced anti-tumor response in a patient.