The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula that are inhibitors of matrix-metalloproteinases and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. The signal processor may process audio signals for the transducer. A via hole is disposed through the alumina dielectric substrate from a body fluid side to a device side. The inventive structure also results in higher uniaxial stress in the MOSFET channel compared to one which allows for a facet to grow at the trench isolation edge.