The invention is directed to a vaccine comprising: i) coxsackie B virus CBV1 and CBV2, and ii) at least one coxsackie B virus selected from CBV3, CBV4, CBV5 and CBV6. The inductive component comprises at least a core assembled from separate structural elements as well as liquid cooling ducts integrated into the core for the purpose of liquid cooling and a winding structure around the core. An offset fixing circuit controls the input stage in accordance with an input voltage of the operational amplifier circuit. The service may, when another provider is willing to provide the consumer with the more favorable first alternate terms, enabling the presentation to the consumer of an offer based on the first alternate terms. The method includes: sensing a physiological signal from the user and outputting the sensed physiological signal; extracting a physiological status based on said sensed physiological signal; and automatically controlling said negative pressure provided to the user’s oral cavity based on said physiological status.