Methods and apparatus are provided for a User Equipment and a base station in communication with each other to determine parameters for a Random Access process. In one embodiment, a phEPOABP polyplex may be administered to a subject in a therapeutically effective amount to treat or prevent a cardiac condition. The mechanism has particular advantages when used with a plurality of functional modules connected to a packet router, whereby a single functional module can generate a current request relating to a current packet and a deferred arbitration request relating to a later packet to be issued a fixed number of cycles after the current request. A channel estimate queue stores a sequence of channel estimates provided by the channel estimator and provides the sequence to a weighted averaging element that outputs an averaged channel estimate.